• Songlin Chen, Cheng Zhang, Xiaorong Liu, Ling Gao, Weixi Zhang, Wen Huang, Xilin Lu, and Zhanhang Wang.
• Department of Neurology, First Affiliated Hospital of Zhong Shan University, Guangzhou 510080, China.
• Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Apr 1; 34 (2): 210-3.

ObjectiveWith a view to further experimental studies on Duchenne muscular dystrophy (DMD), we investigated the motor function, serum creatine kinase (CK) level and pathological characteristics of muscular tissue in C57, mdx, dystrophin/utrophin gene double knockout (dko)mice.MethodsGene identification was performed for the filial generation of heterozygote of utrophin gene knockout of mdx mice for acquiring mdx and dko mice. The motor function, serum CK level, and the pathology of muscular tissue of C57, mdx and dko mice were compared.ResultsThere were significant differences in all detecting aspects between C57 mouse and dko mouse. In the aspects of serum CK level and pathology of muscular tissue, there were differences between C57 mouse and mdx mouse; however, no significant difference in motor function was observed between them.ConclusionCompared with mdx mouse, dko mouse is in a more serious illness state which is nearer to the natural state of DMD. Therefore, dko mouse is a more ideal model for studying the praxiology of DMD.

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