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Case Reports
BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy.
- Chika Yamada, Yoshimitsu Shimomura, Kimimori Kamijyo, Madoka Kanda-Kato, Satoshi Yoshioka, Daisuke Yamashita, and Takayuki Ishikawa.
- Department of Hematology, Kobe City Medical Center General Hospital, Japan.
- Intern. Med. 2021 Oct 1; 60 (19): 3149-3153.
AbstractWe herein report a rare case of BCR-ABL1-positive B-lymphoblastic lymphoma (B-LBL). An 18-year-old woman had a history of persistent left-sided chest pain. Positron emission tomography showed increased metabolic activity in the fifth rib, duodenum, and pancreas. The pathological findings of the pancreas, duodenum, and bone marrow confirmed the diagnosis of B-LBL. Polymerase chain reaction of duodenum and bone marrow also revealed a minor BCR-ABL1 fusion gene. She was diagnosed with BCR-ABL1-positive B-LBL and administered dasatinib and prednisolone. She achieved complete remission two weeks after the initiation of the treatment. She received stem cell transplantation after consolidation chemotherapy and sustained complete remission.
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