• Sijan Basnet, Niranjan Tachamo, Rashmi Dhital, and Biswaraj Tharu.
• Department of Medicine, Reading Hospital and Medical Center, West Reading, PA, USA.
• J Community Hosp Intern Med Perspect. 2018 Jan 1; 8 (3): 152-155.

AbstractDaptomycin is a bactericidal antibiotic approved for treatment of gram-positive skin and soft tissue infections. We present a case of an 89-year-old man who presented with fever, shortness of breath and nonproductive cough on week 4 of starting daptomycin for infective endocarditis. Computerized tomography scan showed bilateral interstitial infiltrates predominantly affecting the lower lobes. He also had peripheral eosinophilia of 6%. He was diagnosed with eosinophilic pneumonia secondary to daptomycin use. His symptoms improved with discontinuation of daptomycin and initiation of corticosteroids. Clinical correlation of pneumonia-like presentation with recent use of daptomycin should make physicians rule out this rare adverse effect for early institution of correct treatment.

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