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Zhongguo Yi Xue Ke Xue Yuan Xue Bao · Dec 2019
Review[N-methyl-D-aspartate Receptor:Potential Role in TreatingNeuraxial Opioid Induced Pruritus].
- Xiao Tan, Le Shen, and Guang Yu Huang.
- Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,Chin.
- Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Dec 30; 41 (6): 851-856.
AbstractNeuraxial opioid administration is one of the most common methods of anesthesia and analgesia,while itching is the most troublesome adverse effect.The current treatments for neuraxial opioid-induced pruritus still have certain limitations.This article reviews the current treatments and basic scientific findings(including neurotransmitters,opioid receptors,and signaling pathways)of pruritus caused by neuraxial opioids.Based on our recent findings on N-methyl-D-aspartate(NMDA)receptors and pruritus caused by neuraxial opioids,we provide new ideas for the treatment of itching caused by neuraxial opioids.Since NMDA receptors may play a key role in neuraxial opioid-induced pruritus,NMDA receptor antagonists can have certain therapeutic advantages.
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