• Journal of medical ethics · Dec 2020

    Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines.

    • Robert Steel, Lara Buchak, and Nir Eyal.
    • Center for Population-Level Bioethics and Department of Philosophy, Rutgers University, New Brunswick, New Jersey, USA.
    • J Med Ethics. 2020 Dec 1; 46 (12): 808-812.

    AbstractTo counter the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), some have proposed accelerating SARS-CoV-2 vaccine development through controlled human infection (or 'challenge') trials. These trials would involve the deliberate exposure of relatively few young, healthy volunteers to SARS-CoV-2. We defend this proposal against the charge that there is still too much uncertainty surrounding the risks of COVID-19 to responsibly run such a trial.© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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