• Internal medicine · Oct 2021

    Case Reports

    A Case of Spontaneous Remission of Thrombospondin Type-1 Domain-Containing-Associated Membranous Nephropathy.

    • Shiika Watanabe, Tomo Suzuki, Wei Han, Mayumi Nakata, Kenichiro Koitabashi, Daisuke Ichikawa, Atsuko Kamijo-Ikemori, Junki Koike, and Yugo Shibagaki.
    • Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan.
    • Intern. Med. 2021 Oct 1; 60 (19): 3125-3128.

    AbstractMembranous nephropathy often achieves spontaneous remission. However, there are scarce reports of spontaneous remission of thrombospondin type-1 domain-containing 7A (THSD7A)-associated membranous nephropathy. A 64-year-old female presented with nephrotic syndrome and edema of the lower extremities. We diagnosed membranous nephropathy by kidney biopsy and confirmed positive THSD7A on immunofluorescence using frozen sections; serum THSD7A antibodies were also detected. Thirty-four months after the initial diagnosis, she achieved a spontaneous complete remission without immunosuppressive therapy. With the complete remission, no serum THSD7A levels were detected. In this study, we describe serial examinations of kidney biopsies and serum THSD7A antibodies.

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