• Braz J Infect Dis · Nov 2017

    Ceftolozane-tazobactam activity against drug-resistant Enterobacteriaceae and Pseudomonas aeruginosa causing healthcare-associated infections in Latin America: report from an antimicrobial surveillance program (2013-2015).

    • Michael A Pfaller, Dee Shortridge, Helio S Sader, Ana Gales, Mariana Castanheira, and Robert K Flamm.
    • JMI Laboratories, North Liberty, IA, United States; University of Iowa, College of Medicine, Iowa City, IA, United States.
    • Braz J Infect Dis. 2017 Nov 1; 21 (6): 627-637.

    AbstractThis study evaluated the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Latin American isolates of Enterobacteriaceae and Pseudomonas aeruginosa from patients with health care-associated infections. Ceftolozane-tazobactam is an antipseudomonal cephalosporin combined with a well-established β-lactamase inhibitor. A total of 2415 Gram-negative organisms (537 P. aeruginosa and 1878 Enterobacteriaceae) were consecutively collected in 12 medical centers located in four Latin American countries. The organisms were tested for susceptibility by broth microdilution methods as described by the CLSI M07-A10 document and the results interpreted according to EUCAST and CLSI breakpoint criteria.Copyright © 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.

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