• Hsi-Lan Huang, Sarah Krull Abe, Norie Sawada, Ribeka Takachi, Junko Ishihara, Motoki Iwasaki, Taiki Yamaji, Hiroyasu Iso, Tetsuya Mizoue, Mitsuhiko Noda, Masahiro Hashizume, Manami Inoue, Shoichiro Tsugane, and JPHC Study Group.
• Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
• Prev Med. 2021 Jul 1; 148: 106561.

BackgroundFew epidemiologic studies have assessed the associations of sugary drink consumption with mortality outcomes among Asian populations.MethodsThis study included 70,486 participants in the Japan Public Health Center-based Prospective Study at the age of 45-74 years in 1995-1999. A validated food frequency questionnaire was used to assess the consumption of sugary drinks. We estimated the risk of total and cause-specific mortality associated with sugary drink consumption using Cox proportional hazards regression model.ResultsMean follow-up was 17.1 years, during which 11,811 deaths were documented. Sugary drink consumption was associated with higher total mortality, with multivariate HR of 1.06 (95% CI 1.00-1.13) for quintile 3, 1.07 (95% CI 1.01-1.13) for quintile 4, and 1.15 (95% CI 1.09-1.22) for quintile 5, compared with quintile 1 (P < 0.001 for trend). Additionally, positive associations with cause-specific mortality were observed, including death from circulatory system diseases (quintile 5 vs quintile 1; HR, 1.23; 95% CI 1.09-1.38) and heart disease (quintile 5 vs quintile 1; HR, 1.35; 95% CI 1.14-1.60).ConclusionIn this large Japanese prospective study, sugary drink consumption was associated with all-cause and cause-specific mortality.Copyright © 2021 Elsevier Inc. All rights reserved.

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