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- Alexander Krüttgen, Christian G Cornelissen, Michael Dreher, Mathias W Hornef, Matthias Imöhl, and Michael Kleines.
- LaboratoryDiagnostic CEnter, University Hospital RWTH Aachen, Germany.
- J. Virol. Methods. 2021 Feb 1; 288: 114024.
AbstractThere is an ongoing need for reliable antigen assays for timely and easy detection of individuals with acute SARS-CoV-2 infection. Using 75 swabs from patients previously tested positive by SARS-CoV-2 PCR and 75 swabs from patients previously tested negative by SARS-CoV-2 PCR, we investigated the sensitivity and specificity of the SARS-CoV-2 Rapid Antigen Test (Roche). We determined a specificity of 96 %. The assay's sensitivity with samples with a cycle threshold of < 25, 25 - <30, 30 - <35, and> = 35 was 100 %, 95 %, 44.8 % and 22.2 %, respectively. We conclude that sensitivity and specificity of the antigen assay is inferior to the PCR assay. However, the antigen assay may be a quick and easy to perform alternative for differentiation of individuals contagious for SARS-CoV-2 from non-contagious individuals.Copyright © 2020 Elsevier B.V. All rights reserved.
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