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Acta neurochirurgica · Oct 2016
ReviewSelective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas.
- Ruichong Ma and Colin Watts.
- Department of Neurosurgery, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Headley Way, Oxford, OX3 9DU, UK. ruichong.ma@gmail.com.
- Acta Neurochir (Wien). 2016 Oct 1; 158 (10): 1935-41.
AbstractMalignant gliomas are locally invasive tumors that offer a poor prognosis. Evidence shows that complete resection of the tumor at the time of surgery confers a significant improvement in overall survival. In recent years, 5- aminolevulinic acid (ALA)-induced fluorescence has been used by neurosurgeons to good effect in increasing the rate of complete resection. Despite the considerable interest in the use of 5-ALA in fluorescence-guided neurosurgery, the mechanisms behind the accumulation of Protoporphyrin IX (PpIX) in neoplastic tissue are unclear. In this review, we summarize the evidence in the literature on the mechanisms underlying the selective production of PpIX with a specific focus on gliomas.
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