• T D Kay, H R Playford, and D W Johnson.
• Department of Renal Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia.
• Clin Nephrol. 2003 Jan 1; 59 (1): 56-8.

AbstractValproate intoxication is a relatively common clinical problem that can result in coma, respiratory depression, pancytopenia, hemodynamic instability and death [Fernandez et al. 1996, Franssen et al. 1999]. The drug's relatively low molecular weight, small volume of distribution and saturable protein-binding render it potentially amenable to extracorporeal removal (hemofiltration, hemodialysis or hemoperfusion), but published experience is scarce. This report describes a woman with a potentially fatal sodium valproate overdose, who did not respond to continuous veno-venous hemodiafiltration, but was successfully treated with low-flux hemodialysis. Based on our experience, we recommend hemodialysis for serious valproate intoxication.

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