• Eur Spine J · Jun 2012

    Modic type I change may predict rapid progressive, deforming disc degeneration: a prospective 1-year follow-up study.

    • Liisa Kerttula, Katariina Luoma, Tapio Vehmas, Mats Grönblad, and Eeva Kääpä.
    • Department of Radiology, Helsinki University Central Hospital, Topeliuksenkatu 5, Helsinki, Finland. liisa.kerttula@hus.fi
    • Eur Spine J. 2012 Jun 1;21(6):1135-42.

    IntroductionThis prospective magnetic resonance imaging (MRI) study in chronic low-back pain (CLBP) patients evaluated the natural course of degenerative lumbar spine changes in relation to Modic 1 type changes (M1) within 1 year.Materials And MethodsFrom 3,811 consecutive CLBP patients referred to lumbar spine MRI 54 patients with a large M1 were selected using strict exclusion criteria to exclude specific back disorders. Follow-up MRI was obtained within 11-18 months.ResultsAt baseline M1 was associated with an adjacent endplate lesion in 96% of the cases. In follow-up, an unstable M1 was associated both with an increase of endplate lesions, decrease of disc height and change in disc signal intensity, most found at L4/5 or L5/S1. In disc spaces without M1, progression of degenerative changes was rare.ConclusionEndplate deformation, decreasing disc height and change of disc signal intensity appear essential features of accelerated degenerative process associated with M1.

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