• Arch Cardiovasc Dis · Aug 2020

    Review

    Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2.

    • Bernard I Lévy, Jean-Pierre Fauvel, and Société Française d’Hypertension Artérielle.
    • Inserm UMR970 (PARCC) and Hôpital Lariboisière, 75010 Paris, France. Electronic address: bernard.levy@inserm.fr.
    • Arch Cardiovasc Dis. 2020 Aug 1; 113 (8-9): 572-578.

    AbstractSevere acute respiratory syndrome coronavirus 2, which is responsible for the current coronavirus disease 2019 pandemic, uses angiotensin-converting enzyme 2 as a gateway into host cells. In this review, we summarise the biology of this enzyme, which plays a key role in cardiovascular homeostasis. Blockers of the renin-angiotensin system modify the expression and activity of angiotensin-converting enzyme 2 in different ways. The effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the expression and enzyme activity of angiotensin-converting enzyme 2 are reviewed, and the consequences of these treatments for the severity of coronavirus disease 2019 infection are discussed.Copyright © 2020 Elsevier Masson SAS. All rights reserved.

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