• Biochem. Biophys. Res. Commun. · May 2018

    Review

    Who and how in the regulation of mitochondrial cristae shape and function.

    • R Quintana-Cabrera, A Mehrotra, G Rigoni, and M E Soriano.
    • Department of Biology, University of Padova, Padova, 35121, Italy; Venetian Institute of Molecular Medicine, Padova 35129, Italy.
    • Biochem. Biophys. Res. Commun. 2018 May 27; 500 (1): 94-101.

    AbstractMitochondrial adaptation to different physiological conditions highly relies on the regulation of mitochondrial ultrastructure, particularly at the level of cristae compartment. Cristae represent the membrane hub where most of the respiratory complexes embed to account for OXPHOS and energy production in the form of adenosine triphosphate (ATP). Changes in cristae number and shape define the respiratory capacity as well as cell viability. The identification of key regulators of cristae morphology and the understanding of their contribution to the mitochondrial ultrastructure and function have become an strategic goal to understand mitochondrial disorders and to exploit as therapeutic targets. This review summarizes the known regulators of cristae ultrastructure and discusses their contribution and implications for mitochondrial dysfunction.Copyright © 2017 Elsevier Inc. All rights reserved.

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