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Randomized Controlled Trial Comparative Study Clinical Trial
Taking the 'sting' out of local anaesthetics.
- C C Long, R J Motley, and P J Holt.
- Department of Dermatology, University Hospital of Wales, Heath Park, Cardiff, U.K.
- Br. J. Dermatol. 1991 Nov 1; 125 (5): 452-5.
AbstractIn order to investigate factors influencing the discomfort caused by the injection of different lignocaine preparations, a randomized, double-blind comparison of paired injections was performed in 32 patients. In all subjects 2% plain lignocaine was found to be more painful than 0.5% plain lignocaine. Lignocaine with adrenaline 1:200,000 was found to be significantly more painful than plain lignocaine. The presence of sodium metabisulphite (the antioxidant in commercial adrenalized lignocaine) significantly increased the discomfort. Neutralization of acidic 0.5% lignocaine (pH 4.7) reduced the discomfort caused in 44% of patients, but this was not statistically significant.
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