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- Yasutaka Mochizuka, Masato Kono, Ryutaro Hirama, Yuiko Oshima, Kenichiro Takeda, Akari Tsutsumi, Hideki Miwa, Yoshihiro Miki, Dai Hashimoto, Toshiki Kimura, Takuro Sakagami, and Hidenori Nakamura.
- Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan.
- Intern. Med. 2021 Oct 15; 60 (20): 3267-3272.
AbstractA 78-year-old man was admitted to our hospital with a fever and left chest pain. Computed tomography showed multiple lung nodules, narrowing of the right bronchus intermedius with mediastinal lymphadenopathy, and an osteolytic lesion. Bronchoscopic findings showed rapid progression of multiple polypoid lesions and the bronchial stenosis. A biopsy of the endobronchial lesions revealed non-necrotizing granulomatous inflammation, and a tissue culture identified Mycobacterium avium. An anti-human immunodeficiency virus antibody was negative. Finally, anti-interferon-gamma (IFN-γ) autoantibodies were detected, and the patient was diagnosed with disseminated nontuberculous mycobacterium infection with anti-IFN-γ autoantibodies. Antimycobacterial therapy was effective, and radiographic findings, including the endobronchial lesions, were resolved.
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