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Di Yi Jun Yi Da Xue Xue Bao · Jun 2002
Changes of serum MDA and SOD levels in ischemia-reperfusion injuries of the limbs in rats preconditioned with heat stress.
- Yong-Jian Sun, Qian Wang, Guo-Xian Pei, Lei Zheng, and Xiong-Jin Tan.
- Department of Orthopedics and Traumatology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
- Di Yi Jun Yi Da Xue Xue Bao. 2002 Jun 1; 22 (6): 506-8.
ObjectiveTo study the effect of pretreatment with heat stress on ischemia-reperfusion injuries of the limbs in rats.MethodsRat models of ischemia-reperfusion injury were established with or without prior heat stress treatment, in which serum malondialdehyde (MDA) level and superoxide dismutase (SOD) activities were measured by means of thiobarbituric acid and nitroblue tetrazolium respectively.ResultsComparison between ischemia-reperfusion group and the control group revealed significantly elevated MDA levels (P<0.01) and depressed SOD activities (P<0.01) in the condition of ischemia-reperfusion injury. Pretreatment with heat stress, however, significantly lowered the elevated MDA levels (P<0.01) and enhanced SOD activities (P<0.01) during ischemia-reperfusion injury.ConclusionPretreatment with heat stress can enhance the activity of SOD to remove free oxygen radicals in the cells.
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