• Mycopathologia · Aug 2020

    Case Reports

    Recurrent Talaromyces marneffei Infection Presenting with Intestinal Obstruction in a Patient with Systemic Lupus Erythematosus.

    • Yu-Kun Zhao, Jing-Ye Liu, Juan-Hua Liu, Sha Lu, Hui-Hui Wu, and Di-Qing Luo.
    • Department of Dermatology, The Eastern Division of The First Affiliated Hospital, Sun Yat-sen University, 183 Huangpu Rd. E., Guangzhou, 510700, People's Republic of China.
    • Mycopathologia. 2020 Aug 1; 185 (4): 717-726.

    AbstractTalaromyces marneffei is an important opportunistic pathogen mainly afflicting the HIV-infected patients, in rare instance, it could cause infection in non-HIV-infected individuals. We report a 51-year-old Chinese woman who, with histories of SLE for 14 years and disseminated talaromycosis for 4 years, occurred partial intestinal obstruction that was demonstrated to be caused by Talaromyces marneffei infection. The randomly amplified polymorphic DNA results of paraffin-embedded tissues from both the present episode and the previous infection suggested that the present infection was a recurrent. The patient was performed excision of involved intestine and treated with oral itraconazole at a daily dose of 400 mg for 3 months, leading to an excellent response. However, she died with unknown reason more than a year later. We also reviewed the literature on Talaromyces marneffei infection associated with SLE as well as intestinal talaromycosis alone.

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