• Anne Keller, Eleanor Boyle, Thomas A Skog, J David Cassidy, and Erik Bautz-Holter.
• Department of Physical Medicine and Rehabilitation, Oslo University Hospital, 0407, Oslo, Norway. Anne.Keller@medisin.uio.no
• Eur Spine J. 2012 Mar 1;21(3):418-24.

BackgroundThere is evidence for an association between Modic type 1 and pain in patients with low back pain (LBP), but little knowledge about its effect on clinical outcomes.Purpose(1) To assess the prevalence of Modic changes, (2) to determine if Modic changes influence the clinical course of LBP, and (3) to identify prognostic factors for recovery.Study Design/SettingProspective clinical cohort study, with a 1-year follow-up. The treatment consisted of brief intervention and instruction in stretching. PATIENT'S SAMPLE: Two hundred and sixty-nine patients with chronic low back pain.Outcome MeasuresSocio-demographic variables, education, profession, self-reported measures, degenerative changes on MRI.MethodsLinear growth model and Cox regression analysis.ResultsFive percent had a normal MRI, 14 and 50% had Modic 1 and Modic 2 changes. Modic changes were not significant covariates for the clinical course of pain, function or fear avoidance beliefs. Education was a strong prognostic factor for recovery.ConclusionsModic changes did not influence the clinical course of back pain and were not prognostic factors for recovery. Education was strongly associated with recovery.

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