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Pacing Clin Electrophysiol · May 2005
Case ReportsQT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone.
- Stavros P Kounas, Konstantinos P Letsas, Antonios Sideris, Michalis Efraimidis, and Fotios Kardaras.
- Second Department of Cardiology, Evagelismos Hospital, Athens, Greece. skounas@hol.gr
- Pacing Clin Electrophysiol. 2005 May 1; 28 (5): 472-3.
AbstractThis report documents the occurrence of torsades de pointes (TdP) caused by marked QT interval prolongation in the case of a 71-year-old woman receiving both metronidazole and amiodarone for the treatment of pseudomembranous colitis and paroxysmal atrial fibrillation. The case highlights a previously unknown drug interaction. The role of inhibition of cytochrome P-450 CYP3A4 is discussed.
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