• Clin Exp Rheumatol · Nov 1999

    Clinical Trial

    Methotrexate and leflunomide combination therapy for patients with active rheumatoid arthritis.

    • P J Mroczkowski, M E Weinblatt, and J M Kremer.
    • Division of Rheumatology, Albany Medical College, New York 12208-3479, USA.
    • Clin Exp Rheumatol. 1999 Nov 1; 17 (6 Suppl 18): S66-8.

    AbstractAn open-label, one-year study was conducted to evaluate the safety and clinical response to leflunomide and methotrexate combination therapy for rheumatoid arthritis. Study results revealed tolerable safety, no significant pharmacokinetic interactions between methotrexate and leflunomide, and suggested improved clinical response with combination therapy.

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