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Sleep medicine clinics · Sep 2019
ReviewFurther Development of P4 Approach to Obstructive Sleep Apnea.
- Allan I Pack.
- Translational Research Laboratories, Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Suite 2100, 125 South 31st Street, Philadelphia, PA 19104-3403, USA. Electronic address: pack@mail.med.upenn.edu.
- Sleep Med Clin. 2019 Sep 1; 14 (3): 379-389.
AbstractObstructive sleep apnea (OSA) is a heterogeneous disorder. Cluster analysis has identified different physiologic subtypes with respect to symptoms. A difference exists in cardiovascular risk from OSA between the 7 subtypes identified. There are 3 basic subtypes replicated in multiple studies: (a) a group where insomnia is the main symptom; (b) an asymptomatic group; (c) a group with marked excessive sleepiness. The symptomatic benefit from treatment with nasal CPAP varies between these 3 subtypes. Data from the Sleep Heart Health Study reveal that the increased risk of cardiovascular disease from OSA occurs only in the excessively sleepy group.Copyright © 2019 Elsevier Inc. All rights reserved.
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