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- Brian Ezekian, Paul M Schroder, Kyle Freischlag, Janghoon Yoon, Jean Kwun, and Stuart J Knechtle.
- Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC.
- Transplantation. 2018 Aug 1; 102 (8): 1213-1222.
AbstractThe purpose of this review is to discuss immunologic tolerance as it applies to solid organ transplantation and to identify barriers that hinder the achievement of this long-term goal. First, the definition of tolerance and an introduction of mechanisms by which tolerance exists or can be achieved will be discussed. Next, a review of contemporary attempts at achieving transplant tolerance will be described. Finally, a discussion of the humoral barriers to transplantation tolerance and potential ways to overcome these barriers will be presented.
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