• Wei Du, Hong Wang, Shu-wen Zhang, and Bao-en Wang.
• Department of Infectious Diseases and Critical Care Medicine, Beijing 100050, China.
• Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005 May 1; 17 (5): 279-81.

ObjectiveTo explore the relationship between the systemic inflammatory response syndrome (SIRS) and the severity of the acute pancreatitis, so as to provide some leads in the treatment to lower the mortality of severe acute pancreatitis.MethodsOne hundred and seventy-two patients suffering from acute pancreatitis admitted to our departments from January 1, 2001 to December 31, 2003 were retrospectively analyzed. The patients were divided into survivor group and non-survivor group, and patients in the survivor group were further divided into severe group and mild group according to scores of acute physiology and chronic health evaluation II (APACHE II). The scores of APACHE II were compared between patients without SIRS and those who met the criteria of SIRS.ResultsThere was significant difference between the survivor group and non-survivor group not only in the incidence of patients who developed SIRS, but also in the number of patients fulfilling or not fulfilling the diagnostic criteria of SIRS between the severe group and mild group. There was also significant statistical difference between the SIRS group and non-SIRS group in the APACHE II scoring. Significant difference in duration of SIRS was found between the severe group and mild group.ConclusionSIRS is highly correlated with the severity of acute pancreatitis. Active prevention and treatment of SIRS may raise the survival rate of severe acute pancreatitis.

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