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- Naoki Tanomogi, Toshinori Otani, Junko Araki, Ayumi Sugitani, Shingo Itagaki, Takahiro Kiriu, and Kota Shimada.
- Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Japan.
- Intern. Med. 2021 Jul 1; 60 (13): 2145-2148.
AbstractWe herein report a fatal case of coronavirus disease 2019 (COVID-19) pneumonia with rapid progression of respiratory failure and lymphopenia. Excessive recruitment and sequestration of lymphocytes in the lung were suggested as the pathophysiology underlying COVID-19-associated lymphopenia. Interestingly, the autopsy in this case revealed lymphocytic infiltration in the lungs even at sites that appeared normal on autopsy imaging. These findings suggest that in COVID-19 cases with risk factors of severe exacerbation, early glucocorticoid administration should be considered, especially if lymphopenia is present, even if the imaging findings show only mild abnormalities.
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