• Clin Cancer Res · Sep 2017

    Letter

    Anti-CD137 and PD-1/PD-L1 Antibodies En Route toward Clinical Synergy.

    • Elisabeth Pérez-Ruiz, Iñaki Etxeberria, Maria E Rodriguez-Ruiz, and Ignacio Melero.
    • Program of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), Pamplona, Spain.
    • Clin Cancer Res. 2017 Sep 15; 23 (18): 5326-5328.

    AbstractT-cell costimulation and coinhibition can be respectively exploited by blocking and agonist mAbs. Both strategies can be synergistically combined in mouse models. Early clinical results from combinations of anti-PD-1 mAbs in conjunction with agonist anti-CD137 (4-1BB) mAbs show excellent safety and promising efficacy. Clin Cancer Res; 23(18); 5326-8. ©2017 AACRSee related article by Tolcher et al., p. 5349.©2017 American Association for Cancer Research.

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