The D614G mutations in the SARS-CoV-2 spike protein:

Biochem. Biophys. Res. Commun. · Jan 2021

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The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design.

The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.

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- Danielle C Groves, Sarah L Rowland-Jones, and Adrienn Angyal.
- Florey Institute for Host-Pathogen Interactions and the Department of Infection, Immunity and Cardiovascular Science (IICD), Sheffield University Medical School, Beech Hill Road, Sheffield, S. Yorkshire, S102RX, United Kingdom.
- Biochem. Biophys. Res. Commun. 2021 Jan 29; 538: 104-107.
AbstractThe development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.Copyright © 2020 Elsevier Inc. All rights reserved.

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The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design.

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The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design.

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