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Forensic Sci Med Pathol · Mar 2015
Case Reports Comparative StudyRickets or abuse? A histologic comparison of rickets and child abuse-related fractures.
- Charis Kepron and Michael S Pollanen.
- Ontario Forensic Pathology Service, Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada, ckepron@toh.on.ca.
- Forensic Sci Med Pathol. 2015 Mar 1; 11 (1): 78-87.
PurposeThe bone changes of vitamin D deficiency rickets have been invoked as an alternate explanation for child-abuse related fractures identified through medical imaging. The lack of modern histopathologic comparisons between these two entities limits the abilities of the forensic pathologist to address this differential diagnosis, both in their autopsy reports and on the witness stand.MethodsWe report a comparison of the histologic appearance of the bones in a two year old child with vitamin D deficiency rickets with fractures occurring in three young children with child abuse.ResultsIn the case of rickets, there was marked architectural disorganization of endochondral ossification at the costochondral junctions and growth plates of long bones. The child abuse-related fractures showed osteochondral callus at different stages of healing, either centered on a discrete fracture line or at metaphyses (e.g. classical metaphyseal lesions). In many instances, the healing fractures disrupted the line of endochondral ossification. In none of the child abuse-related fractures was there any similarity to the histologic appearance of rickets.ConclusionThe maturation disturbance in the growth plate that occurs in rickets is a distinctive entity that cannot be confused histologically with healing fractures, including the classical metaphyseal lesion.
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