• K E Rollins, D Jackson, and P A Coughlin.
• Department of Vascular Surgery, Addenbrooke's Hospital, Cambridge, UK.
• Br J Surg. 2013 Jul 1;100(8):1002-8.

BackgroundCritical leg ischaemia (CLI) has been associated with high mortality rates. There is a lack of contemporary data on both short- and long-term mortality rates in patients diagnosed with CLI.MethodsThis was a systematic literature search for studies prospectively reporting mortality in patients diagnosed with CLI. Meta-analysis and meta-regression models were developed to determine overall mortality rates and specific patient-related factors that were associated with death.ResultsA total of 50 studies were included in the analysis The estimated probability of all-cause mortality in patients with CLI was 3·7 per cent at 30 days, 17·5 per cent at 1 year, 35·1 per cent at 3 years and 46·2 per cent at 5 years. Men had a statistically significant survival benefit at 30 days and 3 years. The presence of ischaemic heart disease, tissue loss and older age resulted in a higher probability of death at 3 years.ConclusionEarly mortality rates in patients diagnosed with CLI have improved slightly compared with previous historical data, but long-term mortality rates are still high.© 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

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