• Eur. J. Neurosci. · Jan 2017

    The perception of affective touch in Parkinson's disease and its relation to small fibre neuropathy.

    • Lewis Kass-Iliyya, Matthew Leung, Andrew Marshall, Paula Trotter, Christopher Kobylecki, Susannah Walker, David Gosal, Maria Jeziorska, Rayaz A Malik, Francis McGlone, and Monty A Silverdale.
    • Greater Manchester Neuroscience Centre, Department of Neurology, Salford Royal NHS Foundation Trust, Stott Lane, Salford, M6 8HD, UK.
    • Eur. J. Neurosci. 2017 Jan 1; 45 (2): 232-237.

    AbstractAffective touch sensation is conducted by a sub-class of C-fibres in hairy skin known as C-Tactile (CT) afferents. CT afferents respond maximally to gentle skin stroking at velocities between 1 and 10 cm/s. Parkinson's disease (PD) is characterised by markedly reduced cutaneous C-fibres. It is not known if affective touch perception is influenced by C-fibre density and if affective touch is impaired in PD compared to healthy controls. We predicted that perceived pleasantness to gentle stroking in PD would correlate with C-afferent density and that affective touch perception would be impaired in PD compared to healthy controls. Twenty-four PD patients and 27 control subjects rated the pleasantness of brush stroking at an optimum CT stimulation velocity (3 cm/s) and two sub-optimal velocities (0.3 and 30 cm/s). PD patients underwent quantification of C-fibre density using skin biopsies and corneal confocal microscopy. All participants rated a stroking velocity of 3 cm/s as the most pleasant with significantly lower ratings for 0.3 and 30 cm/s. There was a significant positive correlation between C-fibre density and pleasantness ratings at 3 and 30 cm/s but not 0.3 cm/s. Mean pleasantness ratings were consistently higher in PD patients compared to control subjects across all three velocities. This study shows that perceived pleasantness to gentle touch correlates significantly with C-fibre density in PD. The higher perceived pleasantness in PD patients compared to controls suggests central sensitisation to peripheral inputs, which may have been enhanced by dopamine therapy.© 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

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