Oral and IV dosing: a method to determine the compartment of drug

J Pharm Sci · Jun 2008

Oral and IV dosing: a method to determine the compartment of drug elimination for two-compartment models.

It has been shown previously that it is impossible to measure the volume of distribution at steady state conclusively for a multicompartment system from an iv bolus dose only. The problem lies in deciding from which compartment elimination of the drug occurs in the compartmental model. ⋯ The two models examined predict different profiles in the absorption phase of an oral profile. An in vivo data set is provided that favours a peripheral elimination explanation of its observed pharmacokinetics, based on the 'goodness of fit'.

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- J W T Yates and P A Arundel.
- Discovery DMPK, AstraZeneca, Alderley Park, Cheshire SK10 4TG, UK. James.Yates@astrazeneca.com
- J Pharm Sci. 2008 Jun 1; 97 (6): 2036-40.
AbstractIt has been shown previously that it is impossible to measure the volume of distribution at steady state conclusively for a multicompartment system from an iv bolus dose only. The problem lies in deciding from which compartment elimination of the drug occurs in the compartmental model. In this paper a new modelling strategy is examined whereby the compartment of elimination may be identified uniquely for the case of two-compartment models. The two models examined predict different profiles in the absorption phase of an oral profile. An in vivo data set is provided that favours a peripheral elimination explanation of its observed pharmacokinetics, based on the 'goodness of fit'.2007 Wiley-Liss, Inc

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Oral and IV dosing: a method to determine the compartment of drug elimination for two-compartment models.

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