• Zhong Nan Da Xue Xue Bao Yi Xue Ban · Apr 2016

    Meta Analysis

    [Meta analysis for the anesthesia effect and adverse reactions of etomidate and propofol on 
the painless abortion surgery].

    • Li Wang, Wen Li, Rui Xu, and Lihui Long.
    • Department of Scientific and Research, Xi'an Medical University, Xi'an 710077, China.
    • Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Apr 1; 41 (4): 427-33.

    ObjectiveTo evaluate the anesthesia effect of etomidate and propofol on painless abortion surgery. 
MethodsAfter screening the Cochrane Library, Pubmed, China National Knowledge Infrastructure (CNKI), WANFANG, VIP database, the literatures regarding the anesthesia effect of etomidate and propofol on painless abortion surgery were collected from 1995 to 2014. The randomized controlled trials (RCTs) were selected, the quality evaluation was performed and the data was analyzed by using RevMan5.3 software.
ResultsA total of 1 130 patients were included in 9 RCTs. The results of Meta analysis were as follows: the anesthesia induction time in the etomidate group was less than that in propofol group (MD=-0.14, 95% CI -0.24 to -0.04, P=0.004); there were more adverse reactions, such as myoclonus, nausea and vomiting, in the etomidate group compared with the propofol group (P<0.001); the incidence of pain in the etomidate group was less than that in the propofol group (P<0.001); there was no significant difference in the incidence of respiratory depression between the 2 groups (P>0.05); the surgery time, analgesia and duration from withdrawal to the wake-up was not significantly different between the 2 groups (P>0.05). 
ConclusionEtomidate had a shorter anesthesia induction time than propofol in the painless abortion surgery. The incidence of reverse reactions such as myoclonus, nausea and vomiting, was more common in application of etomidate, whereas the incidence of injection pain was more common in the use of propofol group. There was no significant difference in respiratory depression between the 2 drugs. The comprehensive efficacy of propofol is better than etomidate.

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