• Annals of surgery · Jul 2015

    Complex Liver Resection Using Standard Total Vascular Exclusion, Venovenous Bypass, and In Situ Hypothermic Portal Perfusion: An Audit of 77 Consecutive Cases.

    • Daniel Azoulay, Chetana Lim, Chady Salloum, Paola Andreani, Umberto Maggi, Tonine Bartelmaos, Denis Castaing, Gérard Pascal, and Feetal Fesuy.
    • *AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire, Villejuif, France †AP-HP Hôpital Henri Mondor, Service de Chirurgie Hépato-Bilio-Pancréatique et Transplantation Hépatique. Créteil, France ‡Inserm, Unité 955, Créteil, France; and §Inserm, Unité 785, Villejuif, France.
    • Ann. Surg.. 2015 Jul 1;262(1):93-104.

    ObjectiveTo identify independent predictors of 90-day mortality after liver resection for patients undergoing standard total vascular exclusion (TVE) with hypothermic portal perfusion and venovenous bypass. The secondary endpoint was to evaluate the long-term outcomes.BackgroundTumors invading the vena cava and/or the hepatocaval confluence are indications for standard TVE. The inclusion of liver hypothermic perfusion permits safe TVE. There are a limited number of reports focusing on this complex technique and no relevant analysis of short-term and long-term results.MethodsSeventy-seven consecutive liver resections performed using standard TVE with hypothermic portal perfusion and venovenous bypass between 1998 and 2010 were analyzed. The independent predictors and rates of 90-day mortality, morbidity, and long-term survival were evaluated.ResultsThe 90-day mortality rate was 19.5% (15 cases). Three independent predictors of mortality were identified: age-adjusted Charlson Comorbidity Index 3 or more (P = 0.0231; odds ratio = 47.565; 95% confidence interval = 1.701-1330.414), tumor size 10 cm or more (P = 0.0442; odds ratio = 6.374; 95% confidence interval = 1.049-38.734), and the presence of 50/50 criteria (P = 0.0407; odds ratio = 6.217; 95% confidence interval = 1.080-35.782). The overall 5-year survival rate was 30.4%.ConclusionsLiver resection using standard TVE with hypothermic portal perfusion and venovenous bypass is associated with a high mortality rate. The identification of preoperative predictors of mortality should improve the selection of patients for this aggressive surgery. Compared with nonsurgical management, the long-term results are acceptable and justify this aggressive surgery in selected patients.

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