• R Lumb and D Shaw.
• Division of Clinical Microbiology, Institute of Medical and Veterinary Science, Adelaide, SA.
• Med. J. Aust. 1992 Feb 17; 156 (4): 286-7.

ObjectiveTo report a case of progressive disease caused by Mycobacterium bovis after BCG vaccination in a patient asymptomatically infected with the human immunodeficiency virus (HIV).Clinical FeaturesA 34-year-old white man about to commence employment as a developmental care worker had a BCG vaccination. Five months later, he had a positive result to a serological test for HIV antibody. Nine months after BCG vaccination, he presented with fever (38.7 degrees C), a large left axillary lymph node and a small left pleural effusion. The lymph node was biopsied and acid-fast bacilli observed in Ziehl-Neelsen stained smears. Culture grew Mycobacterium bovis (BCG).Treatment And OutcomeHe was successfully treated with isoniazid, rifampicin and ethambutol for a period of nine months.ConclusionBCG vaccination of asymptomatic HIV-positive patients is not recommended. The detection of those at risk for HIV infection before vaccination administration is essential. Self-exclusion based on information supplied to all potential recipients is likely to be the most effective method.

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