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- Cancer Discov. 2018 Dec 1; 8 (12): 1499-1500.
AbstractA case report highlights a novel, rare mechanism of resistance to chimeric antigen receptor (CAR) T-cell therapy, conferred by the accidental transduction of a single leukemic B cell with the anti-CD19 CAR (CAR19) gene during therapy manufacturing. Because CAR19 bound directly to CD19 on the cell surface-a phenomenon called in cis epitope masking-the therapeutic target was effectively hidden from reprogrammed T cells.©2018 American Association for Cancer Research.
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