• Ronald P DeMatteo, Karla V Ballman, Cristina R Antonescu, Christopher Corless, Violetta Kolesnikova, Margaret von Mehren, Martin D McCarter, Jeffrey Norton, Robert G Maki, Peter W T Pisters, George D Demetri, Murray F Brennan, Kouros Owzar, and American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team for the Alliance for Clinical Trials in Oncology.
• *Memorial Sloan-Kettering Cancer Center, New York, NY †Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN ‡Oregon Health Sciences University, Portland, OR §Fox Chase Cancer Center, Philadelphia, PA ¶University of Colorado School of Medicine, Aurora, CO ‖Stanford University School of Medicine, Stanford CA **Mt Sinai School of Medicine, New York, NY ††University of Texas MD Anderson Cancer Center, Houston, TX ‡‡Dana Farber Cancer Institute, Boston, MA; and §§Alliance Statistics and Data Center, Duke University, Durham, NC.
• Ann. Surg. 2013 Sep 1; 258 (3): 422-9.

ObjectiveTo conduct the first adjuvant trial of imatinib mesylate for treatment of gastrointestinal stromal tumor (GIST).BackgroundGIST is the most common sarcoma. Although surgical resection has been the mainstay of therapy for localized, primary GIST, postoperative tumor recurrence is common. The KIT protooncogene or, less frequently, platelet-derived growth factor receptor alpha is mutated in GIST; the gene products of both are inhibited by imatinib mesylate.MethodsThis was a phase II, intergroup trial led by the American College of Surgeons Oncology Group, registered at ClinicalTrials.gov as NCT00025246. From September 2001 to September 2003, we accrued 106 patients who had undergone complete gross tumor removal but were deemed at high risk for recurrence. Patients were prescribed imatinib 400 mg per day for 1 year and followed with serial radiologic evaluation. The primary endpoint was overall survival (OS).ResultsAfter a median follow-up of 7.7 years, the 1-, 3-, and 5-year OS rates were 99%, 97%, and 83%, which compared favorably with a historical 5-year OS rate of 35%. The 1-, 3-, and 5-year recurrence-free survival (RFS) rates were 96%, 60%, and 40%. On univariable analysis, age and mitotic rate were associated with OS. On multivariable analysis, the RFS rate was lower with increasing tumor size, small bowel site, KIT exon 9 mutation, high mitotic rate, and older age.ConclusionsAdjuvant imatinib in patients with primary GIST who are at high risk of recurrence prolongs OS compared with that of historical controls. Optimal duration of adjuvant therapy remains undefined. (NCT00025246).

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