• Clin Exp Rheumatol · Jan 2016

    Cumulated organ damage is associated with arterial stiffness in women with systemic lupus erythematosus irrespective of renal function.

    • José Mario Sabio, José Antonio Vargas-Hitos, Josefina Martínez-Bordonado, Nuria Navarrete-Navarrete, Antonio Díaz-Chamorro, Carmen Olvera-Porcel, and Juan Jiménez-Alonso.
    • Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, Granada, Spain. jomasabio@gmail.com.
    • Clin Exp Rheumatol. 2016 Jan 1; 34 (1): 53-7.

    ObjectivesTo determine whether there is an association between cumulated organ damage and arterial stiffness in women with systemic lupus erythematosus (SLE) with normal renal function and without renal damage.MethodsEighty-eight SLE women with normal renal function and without renal damage, and 102 sex- and age-matched controls with no history of coronary heart disease or peripheral arterial disease were studied. Cumulated organ damage and arterial stiffness were measured using the SLICC/ACR Damage Index (SDI) and pulse wave velocity (PWV), respectively. Patients were categorised as with (SDI ≥1) or without cumulated organ damage (SDI=0) and bivariate analyses were performed to compare both groups. A multivariate logistic regression was carried out to analyse the independent factors associated with cumulated organ damage. A multiple linear regression analysis was used to investigate the correlation between SDI and PWV, adjusted for appropriate confounders.ResultsPWV was significantly higher in patients with respect to controls (p=0.007). Also, patients with SDI ≥1 had significantly higher PWV than those with SDI=0 (p=0.007). In the multivariate analysis, cumulated organ damage was significantly associated with PWV (p=0.006) and obesity (p=0.003). Furthermore, PWV correlated with SDI after adjustment for age, SLE duration, systolic blood pressure, body mass index, renal function, prednisone and homocysteine (r=0.283, p=0.011). Patients with increased PWV were more likely to have organ damage (SDI ≥1) than those with normal PWV (67% vs. 36%, p=0.023).ConclusionsCumulated organ damage was found to be independently associated with the arterial stiffness in SLE women without renal involvement.

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