• Adam A Dmytriw, Richa Chibbar, Petty Pin Yu Chen, Michael D Traynor, Dong Wook Kim, Fernando P Bruno, Christopher C Cheung, Anuj Pareek, ChouAndrew Chia ChenACCDepartment of Orthopaedic Surgery, Singapore General Hospital, Singapore., Jeffrey Graham, Mahmoud Dibas, Geeta Paranjape, Natalie L Reierson, Shelby Kamrowski, Jacob Rozowsky, Averi Barrett, Megan Schmidt, Disha Shahani, Kathryn Cowie, Amber R Davis, Mohamed Abdelmegeed, Jillienne C Touchette, Kevin M Kallmes, John M Pederson, and Praneeth Reddy Keesari.
• Neuroradiology & Neurointervention Service, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
• Expert Rev Respir Med. 2021 Oct 1; 15 (10): 1347-1354.

IntroductionAcute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) often leads to mortality. Outcomes of patients with COVID-19-related ARDS compared to ARDS unrelated to COVID-19 is not well characterized.Areas CoveredWe performed a systematic review of PubMed, Scopus, and MedRxiv 11/1/2019 to 3/1/2021, including studies comparing outcomes in COVID-19-related ARDS (COVID-19 group) and ARDS unrelated to COVID-19 (ARDS group). Outcomes investigated were duration of mechanical ventilation-free days, intensive care unit (ICU) length-of-stay (LOS), hospital LOS, and mortality. Random effects models were fit for each outcome measure. Effect sizes were reported as pooled median differences of medians (MDMs), mean differences (MDs), or odds ratios (ORs).Expert OpinionTen studies with 2,281 patients met inclusion criteria (COVID-19: 861 [37.7%], ARDS: 1420 [62.3%]). There were no significant differences between the COVID-19 and ARDS groups for median number of mechanical ventilator-free days (MDM: -7.0 [95% CI: -14.8; 0.7], p = 0.075), ICU LOS (MD: 3.1 [95% CI: -5.9; 12.1], p = 0.501), hospital LOS (MD: 2.5 [95% CI: -5.6; 10.7], p = 0.542), or all-cause mortality (OR: 1.25 [95% CI: 0.78; 1.99], p = 0.361). Compared to the general ARDS population, results did not suggest worse outcomes in COVID-19-related ARDS.

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