• Cristina Lalmolda, Hector Prados, Georgina Mateu, Mariona Noray, Xavier Pomares, and Manel Luján.
• Fundación Parc Tauli, Sabadell, Barcelona, Spain; Centro de Investigación Biomédica en Red, enfermedades respiratorias, CIBERES, Barcelona, Spain. Electronic address: clalmolda@tauli.cat.
• Arch. Bronconeumol. 2019 May 1; 55 (5): 246-251.

IntroductionThe aim of this study was to assess several air-pressure settings for MI-E to determine their effect on peak cough flow (PCF), and to compare the best pressures with those are more common used in the literature (±40cmH2O) in patients with neuromuscular disorders (NMD).MethodsAdults with NMD in whom MI-E was indicated were recruited. Assisted PCF was measured by an external pneumotachograph. The protocol included 9 PCF measures per patient: 1 baseline (non-assisted), 4 with increasing inspiratory pressures without negative pressure (10, 20, 30 and 40cmH2O or maximum tolerated), and then 4 adding expiratory pressures (-10, -20, -30 and -40cmH2O or maximum tolerated) with maximum inspiratory pressure previously achieved.ResultsTwenty one patients were included, 61% with amyotrophic lateral sclerosis (ALS). Mean PCFs with recommended pressures (±40cmH2O) were lower than the scored in the individualized steps of the titration protocol (197.7±67l/min vs 214.2±60l/min, p<0.05). Regarding subgroups, mean PCFmax values in ALS patients with bulbar symptoms were significantly higher than those achieved with recommended pressures (163.6±80 vs 189±66l/min, p<0.05).ConclusionThe PCFmax obtained with the protocol did not always match the recommended settings. It may be advisable to perform MI-E titration assessed by non-invasive PCF monitoring in patients with NMD, especially in ALS with bulbar involvement to improve the therapy detecting airway collapse induced by high pressures.Copyright © 2018 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.

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