• Mark A Attiah, Casey H Halpern, Usha Balmuri, Piergiuseppe Vinai, Shivan Mehta, Gordon H Baltuch, Noel N Williams, Thomas A Wadden, and Sherman C Stein.
• Center for Functional and Restorative Neurosurgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19106, USA.
• Ann. Surg.. 2012 Aug 1;256(2):251-4.

ObjectiveThe present meta-regression pools data from reports of long-term follow-up (>2 years) to assess durability of the efficacy associated with Roux-en-Y gastric bypass (RYGB) surgery.Data SourcesMedline and PubMed searches for articles pertaining to long-term weight loss after RYGB surgery were performed.BackgroundVarious studies have consistently shown short-term (<2 years) efficacy of RYGB surgery for morbid obesity, corroborated by meta-analytic techniques. Relatively few studies have assessed efficacy over longer periods of time. This is the first meta-analysis to analyze long-term effects of RYGB surgery on weight loss.MethodsTwenty-two reports with a total of 4206 patient cases were included. Sixteen of the 22 studies had multiple follow-up times, ranging from 2 to 12.3 years (mean: 3.6 years). An inverse variance weighted model and meta-regression were used to generate the pooled percent mean excess weight loss (EWL) and the durability of EWL over time, respectively.ResultsMeta-regression did not reveal any significant change in EWL over time. Pooled mean EWL was 66.5%, and there was no significant association between EWL and length of follow-up.ConclusionsPooling data from multiple studies meta-analytically revealed that weight loss after RYGB is maintained over the long-term. Further investigation would be necessary to ascertain similar durability in comorbidity reduction after RYGB surgery.

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