• Lara Senekjian and Raminder Nirula.
• Division of General Surgery, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. lara.senekjian@hsc.utah.edu
• J. Am. Coll. Surg.. 2013 Jan 1;216(1):34-40.

BackgroundLaparoscopic appendectomy (LA) is increasingly being performed in the United States, despite controversy about differences in infectious complication rates compared with open appendectomy (OA). Subpopulations exist in which infectious complication rates, both surgical site and organ space, differ with respect to LA compared with OA.Study DesignAll appendectomies in the National Surgical Quality Improvement Program database were analyzed with respect to surgical site infection (SSI) and organ space infection (OSI). Multivariate logistic regression analysis identified independent predictors of SSI or OSI. Probabilities of SSI or OSI were determined for subpopulations to identify when LA was superior to OA.ResultsFrom 2005 to 2009, there were 61,830 appendectomies performed (77.5% LA), of which 9,998 (16.2%) were complicated (58.7% LA). The risk of SSI was considerably lower for LA in both noncomplicated and complicated appendicitis. Across all ages, body mass index, renal function, and WBCs, LA was associated with a lower probability of SSI. The risk of OSI was considerably greater for LA in both noncomplicated and complicated appendicitis. In complicated appendicitis, OA was associated with a lower probability of OSI in patients with WBC >12 cells × 10(3)/μL. In noncomplicated appendicitis, OA was associated with a lower probability of OSI in patients with a body mass index <37.5 when compared with LA.ConclusionsSubpopulations exist in which OA is superior to LA in terms of OSI, however, SSI is consistently lower in LA patients.Copyright © 2013 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

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