• Experimental gerontology · May 2019

    Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease.

    • Trine B Opstad, Are A Kalstad, Alf Åge Pettersen, Harald Arnesen, and Ingebjørg Seljeflot.
    • Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ullevål, Norway; Center for Heart Failure Research, Oslo University Hospital, Norway; Faculty of Medicine, University of Oslo, Norway. Electronic address: trineoa@medisin.uio.no.
    • Exp. Gerontol. 2019 May 1; 119: 53-60.

    AbstractTelomere length (TL), growth differentiate factor (GDF)11, insulin growth factor (IGF)1, sirtuin (SIRT)1 and inflammatory processes have been related to ageing and age-related diseases, like coronary artery disease (CAD). We aimed to investigate the associations between leukocyte TLs (LTLs), chronological age, sex and comorbidities in CAD patients. Any covariations between LTL, GDF11, IGF1, SIRT-1 and pro-inflammatory cytokines were further assessed.Copyright © 2019 Elsevier Inc. All rights reserved.

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