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- Dimitrios Chatzistefanidis, Leandros Lazaros, Katerina Giaka, Iliada Nakou, Meropi Tzoufi, Ioannis Georgiou, Athanassios Kyritsis, and Sofia Markoula.
- Department of Neurology, University of Ioannina, Ioannina, Greece.
- Pharmacogenomics. 2016 Jun 1; 17 (8): 827-35.
AimThe role of UGT1A6 and UGT2B7 polymorphisms and the impact of total drug plasma concentration in valproic acid (VPA) pharmacogenomics.Patients & MethodsA total of 134 Greek patients were recruited (76 adults). Patients were genotyped for UGT1A6 19T>G, 541A>G and 552A>C and UGT2B7 802T>C polymorphisms. Patients' demographic and clinical data were registered. Natural logarithm of concentration-to-dose ratio (CDR) was also calculated as the final outcome.ResultsNo significant genotype-related differences in VPA metabolism were noted among various subgroups. An increased lnCDR ratio was noted in children patients compared with adults suggesting increased metabolic capability in younger ages.ConclusionUGT1A6 and UGT2B7 genotypes were not related to significant changes in VPA metabolism, even after controlling for total drug concentration levels. Younger ages were associated with increased VPA clearance rate.
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