• Cell proliferation · Jan 2020

    Review

    Long non-coding RNAs in cutaneous biology and proliferative skin diseases: Advances and perspectives.

    • Lipeng Tang, Yongxin Liang, Hesong Xie, Xiaozhi Yang, and Guangjuan Zheng.
    • Department of Pharmacology of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
    • Cell Prolif. 2020 Jan 1; 53 (1): e12698.

    AbstractAdvances in transcriptome sequencing have revealed that the genome fraction largely encodes for thousands of non-coding RNAs. Long non-coding RNAs (lncRNAs), which are a class of non-protein-coding RNAs longer than approximately 200 nucleotides in length, are emerging as key epigenetic regulators of gene expression recently. Intensive studies have characterized their crucial roles in cutaneous biology and diseases. In this review, we address the promotive or suppressive effects of lncRNAs on cutaneous physiological processes. Then, we focus on the pathogenic role of dysfunctional lncRNAs in a variety of proliferative skin diseases. These evidences suggest that lncRNAs have indispensable roles in the processes of skin biology. Additionally, lncRNAs might be promising biomarkers and therapeutic targets for cutaneous disorders.© 2019 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.

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