• Biomaterials · Nov 2010

    The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF.

    • Weibang Liang, Qianqian Han, Wei Jin, Zhifeng Xiao, Jingchun Huang, Hongbin Ni, Bing Chen, Jie Kong, Jun Wu, and Jianwu Dai.
    • Department of Neurosurgery, The Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210008, China.
    • Biomaterials. 2010 Nov 1; 31 (33): 8634-41.

    AbstractSpinal cord crushed injury is clinically common. Promoting targeted neural regeneration at the crushed site of spinal cord could be important for the repair. It has been demonstrated in our previous work that native human BDNF fused with a collagen-binding domain (CBD-BDNF) can bind to collagen specifically to exert the neurotrophic effect on promoting axonal regeneration. After injury, collagen is highly accumulated at the injury site. We thus speculate that CBD-BDNF will bind to the extracellular matrix collagen and concentrate at the injury site to improve the therapy. Using the rat spinal cord crushed injury model, we have found that CBD-BDNF by one-time intrathecally injection could be retained and concentrated at the injury site for a longer time than native BDNF without collagen-binding domain. CBD-BDNF could promote better neural regeneration and locomotion recovery.Copyright © 2010 Elsevier Ltd. All rights reserved.

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