• J. Cardiovasc. Electrophysiol. · Jan 2009

    Long- and short-term temporal stability of complex fractionated atrial electrograms in human left atrium during atrial fibrillation.

    • Daniel Scherr, Darshan Dalal, Aamir Cheema, Saman Nazarian, Ibrahim Almasry, Kenneth Bilchick, Alan Cheng, Charles A Henrikson, David Spragg, Joseph E Marine, Ronald D Berger, Hugh Calkins, and Jun Dong.
    • Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    • J. Cardiovasc. Electrophysiol. 2009 Jan 1; 20 (1): 13-21.

    BackgroundComplex fractionated atrial electrograms (CFAEs) have been reported as targets for catheter ablation of atrial fibrillation (AF). However, the temporal stability of CFAE sites remains poorly defined.Methods And ResultsThe study consisted of two phases. In the initial phase, two automated software algorithms, namely the interval confidence level (ICL) and the average interpotential interval (AIPI) were assessed for their diagnostic accuracy for automated CFAE detection. The AIPI was found to be superior to the ICL, and an AIPI of ConclusionCFAEs recorded in the LA during AF display high temporal stability in patients with persistent AF. The clinical significance of our findings warrants further investigation.

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