• Crit. Rev. Oncol. Hematol. · Apr 2015

    Review Meta Analysis

    Pancreatitis with vascular endothelial growth factor receptor tyrosine kinase inhibitors.

    • Pooja Ghatalia, Charity J Morgan, Toni K Choueiri, Pedro Rocha, Gurudatta Naik, and Guru Sonpavde.
    • Department of Internal Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
    • Crit. Rev. Oncol. Hematol. 2015 Apr 1; 94 (1): 136-45.

    AbstractA trial-level meta-analysis was conducted to determine the relative risk (RR) of pancreatitis associated with multi-targeted vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI). Eligible studies included randomized phase 2 and 3 trials comparing arms with and without an FDA-approved VEGFR TKI (sunitinib, sorafenib, pazopanib, axitinib, vandetanib, cabozantinib, ponatinib, regorafenib). Statistical analyses calculated the RR and 95% confidence intervals (CI). A total of 10,578 patients from 16 phase III trials and 6 phase II trials were selected. The RR for all grade and high-grade pancreatitis for the TKI vs. no TKI- arms was 1.95 (p=0.042, 95% CI: 1.02 to 3.70) and 1.89 (p=0.069, 95% CI: 0.95 to 373), respectively. No differential impact of malignancy type or specific TKI agent was seen on RR of all grade of high grade pancreatitis. Better patient selection and monitoring may mitigate the risk of severe pancreatitis. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

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