• Leukemia & lymphoma · May 2016

    Bone marrow abnormalities and early bone lesions in multiple myeloma and its precursor disease: a prospective study using functional and morphologic imaging.

    • Manisha Bhutani, Baris Turkbey, Esther Tan, Neha Korde, Mary Kwok, Elisabet E Manasanch, Nishant Tageja, Sham Mailankody, Mark Roschewski, Marcia Mulquin, Ashley Carpenter, Elizabeth Lamping, Alex R Minter, Brendan M Weiss, Esther Mena, Liza Lindenberg, Katherine R Calvo, Irina Maric, Saad Z Usmani, Peter L Choyke, Karen Kurdziel, and Ola Landgren.
    • a Multiple Myeloma Section , Lymphoid Malignancies Branch, CCR, NCI, NIH , Bethesda , MD , USA ;
    • Leuk. Lymphoma. 2016 May 1; 57 (5): 1114-21.

    AbstractThe incidence and importance of bone marrow involvement and/or early bone lesions in multiple myeloma (MM) precursor diseases is largely unknown. This study prospectively compared the sensitivity of several imaging modalities in monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM) and MM. Thirty patients (10 each with MGUS, SMM and MM) were evaluated with skeletal survey, [18F]FDG-PET/CT, [18F]NaF-PET/CT and morphologic dynamic contrast enhanced (DCE)-MRI. An additional 16 SMM patients had skeletal surveys and FDG-PET/CT. Among MGUS patients, DCE-MRI found only one focal marrow abnormality; other evaluations were negative. Among 26 SMM patients, five (19%) were re-classified as MM based on lytic bone lesions on CT and six had unifocal or diffuse marrow abnormality. Among MM, marrow abnormalities were observed on FDG-PET/CT in 8/10 patients and on DCE-MRI in nine evaluable patients. Abnormal NaF uptake was observed only in MM patients with lytic lesions on CT, providing no additional clinical information.

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