• Internal medicine · Oct 2018

    Case Reports

    Disseminated Mycobacterium avium Infection Presenting with Bladder Lesions in a Patient with Interferon-γ-neutralizing Autoantibodies.

    • Koichi Miyashita, Shun Matsuura, Kenichi Tajima, Shogo Tajima, Ami Aoki, Takuro Sakagami, Naoki Koshimizu, Mikio Toyoshima, and Takafumi Suda.
    • Department of Respiratory Medicine, Fujieda City General Hospital, Japan.
    • Intern. Med. 2018 Oct 15; 57 (20): 3041-3045.

    AbstractA 63-year-old woman presented with a fever, eruption, and sterile pyuria. A cystoscopic examination revealed submucosal nodular lesions in the trigone of the bladder, and a biopsy specimen showed epithelioid cell granulomas in the lamina propria of the bladder. Mycobacterium avium grew in the urine culture. Other organ involvement, such as the lungs, spleen, bones, muscles, and pelvic lymph nodes, was observed on radiological examinations, and M. avium was isolated from some organ lesions. Interferon-γ-neutralizing autoantibodies were detected in the patient's serum. Therefore, the patient was diagnosed with disseminated M. avium infection, which was resolved with antimycobacterial treatment.

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