• Virchows Arch. · Feb 2021

    Review Case Reports

    Histiocyte-rich rhabdomyoblastic tumor: a report of two cases and a review of the differential diagnoses.

    • Melanie Bourgeau and Anthony P Martinez.
    • Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, 30322, USA.
    • Virchows Arch. 2021 Feb 1; 478 (2): 367-373.

    AbstractHistiocyte-rich rhabdomyoblastic tumor is a recently described skeletal muscle neoplasm of uncertain malignant potential, characterized by slow growth, a fibrous capsule containing peripheral lymphoid aggregates, spindle-to-epithelioid cells with a rhabdomyoblastic immunophenotype, and a dense histiocytic infiltrate. It most commonly arises within the muscles of the lower legs and trunk in young-to-middle-aged men, and initial reports suggest indolent behavior. In this paper, we present two additional cases of histiocyte-rich rhabdomyoblastic tumor with similar clinicopathologic features and discuss the differential diagnosis including its overlap with inflammatory leiomyosarcoma.

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